Silvia Neri

Silvia Neri

I am Silvia Neri, 27 years old. I graduated in Pharmaceutical Biotechnology at the University of Perugia, Italy. I am currently a PhD student at the department of Molecular Cellular Hemostasis, Red Cell Laboratory in Sanquin Research centre, Amsterdam.

Expectations

My research project aim to study the interactions that result in RBCs captured in the spleen, either between RBCs and macrophages or RBCs and the extracellular matrix, which will be defined under flow conditions. This will lead to novel insights on the mechanisms that underlie RBC clearance during normal RBC turnover and in different pathological conditions such as sickle cell disease and malaria. In addition, by defining the interactions that occur in the spleen and which form the basis of RBC capturing in this organ, I will be able to improve lab-on-a-chip based diagnostics to predict clearance of RBC in the spleen.

In order to achieve these goals I will gain technical expertise and knowledge in RBC and macrophage research, proteomics, mass spectrometry, advanced microscopy, flow cytometry, cell culture, primary blood cells isolation, phagocytosis assays, mRNA, RNA and DNA analysis, RT qPCR, western blot, flow assay and data analysis.