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We are hiring a further ESR

We have a vacancy for a PhD candidate on "Red Blood Cell Oxidative Stress Response". Candidate should preferably have a biomedical background, or an MD wanting to pursue a scientific career. Affinity with red blood cell disorders such as Sickle cell, Thalassemia, G6PD-deficiency, and membrane disorders is a bonus.
This PhD position is part of a larger EU research consortium. The objective of the consortium and the EU Marie Curie funding is to create the future international research networks. Therefore the candidate should not currently be living in the Netherlands.

Work location is University Medical Center Utrecht.
 

Research topics:

Do all forms of oxidative stress induce the same type of response? Or are there responses for the different forms of oxidative stress (i.e. superoxide anions, hydrogen peroxide, reactive oxygen species). What are the individual differences in oxidative stress response? E.g. in G6PD deficiency: paracetamol can be given safely to one person but should be avoided for another person. What are the factors that determine these differences? (e.g. G6PD genotype, cellular anti-oxidant status, reduced glutathione content). What is the pathophysiological mechanism(s) involved in oxidative stress-related hemolysis? What is the role of shear? Can the ultimate effect, i.e. hemolysis, be prevented with reducing agents, such as anti-oxidants (e.g. n-acetylcysteine), RCB deformability improving agents (Poloxamer, Gardos channel blockers), or monoclonal antibodies that reduce the adhesion between RBC and endothelium (Crizanlizumab). How does G6PD-deficiency compare to other red cell disorders such as sickle cell anaemia or thalassemia. What does an oxidative stress inducing disorder mean for these "continuously stressed" individuals.
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Interested? Please contact Jan.dezoeten(ELIMINAR)@RRmechatronics.com